Successful treatment of two relapsed/refractory t(8;21) acute myeloid leukemia patients by CD19-directed chimeric antigen receptor T cells

Changju Qu; Zheng Li; Liqing Kang; Ying Wang; Haiping Dai; Jia Yin; Guanghua Chen; Mingqing Zhu; Li Yao; Ting Xu; Xiaopeng Tian; Yang Xu; Jia Chen; Xiaming Zhu; Lei Yu; Depei Wu; Xiaowen Tang

doi:10.1038/s41409-018-0423-y

Successful treatment of two relapsed/refractory t(8;21) acute myeloid leukemia patients by CD19-directed chimeric antigen receptor T cells

Bone Marrow Transplant. 2019 Jul;54(7):1138-1140. doi: 10.1038/s41409-018-0423-y. Epub 2019 Jan 10.

Authors

Changju Qu^{1

2

3}, Zheng Li^{1

2

3}, Liqing Kang^{4

5}, Ying Wang⁶, Haiping Dai^{1

2

3}, Jia Yin^{1

2

3}, Guanghua Chen^{1

2

3}, Mingqing Zhu^{1

2

3}, Li Yao^{1

2

3}, Ting Xu^{1

2

3}, Xiaopeng Tian^{1

2

3}, Yang Xu^{1

2

3}, Jia Chen^{1

2

3}, Xiaming Zhu^{1

2

3}, Lei Yu^{4

5}, Depei Wu^{1

2

3}, Xiaowen Tang^{7

8

9}

Affiliations

¹ Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, 215000, Suzhou, China.
² Institute of Blood and Marrow Transplantation, 215000, Suzhou, China.
³ Collaborative Innovation Center of Hematology, Soochow University, 215123, Suzhou, China.
⁴ College of Chemistry and Molecular Engineering, East China Normal University, 200062, Suzhou, China.
⁵ Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd, 201203, Suzhou, China.
⁶ Department of Hematology, The First People's Hospital of Lianyungang, 222061, Suzhou, China.
⁷ Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, 215000, Suzhou, China. xwtang1020@163.com.
⁸ Institute of Blood and Marrow Transplantation, 215000, Suzhou, China. xwtang1020@163.com.
⁹ Collaborative Innovation Center of Hematology, Soochow University, 215123, Suzhou, China. xwtang1020@163.com.

PMID: 30631098
DOI: 10.1038/s41409-018-0423-y

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antigens, CD19*
Chromosomes, Human, Pair 21 / genetics*
Chromosomes, Human, Pair 8 / genetics*
Humans
Immunotherapy, Adoptive*
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / therapy
Male
Translocation, Genetic*

Substances

Antigens, CD19
CD19 molecule, human