A severely debilitated, free-living adult female European hedgehog (Erinaceus europaeus) was presented for rehabilitation. It died overnight, and postmortem examination revealed a closed pyometra. Histopathology confirmed metritis with endometrial hyperplasia, and Staphylococcus lentus was isolated from the purulent uterine material. Staphylococcus lentus has not been previously reported to cause infections in European hedgehogs.