GAD1 gene polymorphisms are associated with bipolar I disorder and with blood homovanillic acid levels but not with plasma GABA levels

Aurora Arrúe; Miguel Angel González-Torres; Nieves Basterreche; Ainara Arnaiz; Olga Olivas; M Isabel Zamalloa; Leire Erkoreka; Ana Catalán; Mercedes Zumárraga

doi:10.1016/j.neuint.2019.01.004

GAD1 gene polymorphisms are associated with bipolar I disorder and with blood homovanillic acid levels but not with plasma GABA levels

Neurochem Int. 2019 Mar:124:152-161. doi: 10.1016/j.neuint.2019.01.004. Epub 2019 Jan 6.

Authors

Aurora Arrúe¹, Miguel Angel González-Torres², Nieves Basterreche³, Ainara Arnaiz⁴, Olga Olivas⁵, M Isabel Zamalloa⁶, Leire Erkoreka⁷, Ana Catalán², Mercedes Zumárraga⁶

Affiliations

¹ Departamento de Investigación Neuroquímica, Hospital de Zamudio, Red de Salud Mental de Bizkaia, Zamudio, Spain; BioCruces Health Research Institute, Barakaldo, Spain. Electronic address: aurora.arrueulles@osakidetza.eus.
² BioCruces Health Research Institute, Barakaldo, Spain; Servicio de Psiquiatría, Hospital Universitario Basurto, Bilbao, Spain; Departamento de Neurociencias, University of the Basque Country (UPV/EHU), Leioa, Spain.
³ BioCruces Health Research Institute, Barakaldo, Spain; Departamento de Neurociencias, University of the Basque Country (UPV/EHU), Leioa, Spain; Unidad de Hospitalización de Corta Estancia, Hospital de Zamudio, Red de Salud Mental de Bizkaia, Zamudio, Spain.
⁴ BioCruces Health Research Institute, Barakaldo, Spain; Servicio de Rehabilitación, Hospital de Zamudio, Red de Salud Mental de Bizkaia, Zamudio, Spain.
⁵ BioCruces Health Research Institute, Barakaldo, Spain; Centro de Salud Mental de Gernika, Red de Salud Mental de Bizkaia, Gernika, Spain.
⁶ Departamento de Investigación Neuroquímica, Hospital de Zamudio, Red de Salud Mental de Bizkaia, Zamudio, Spain; BioCruces Health Research Institute, Barakaldo, Spain.
⁷ BioCruces Health Research Institute, Barakaldo, Spain; Departamento de Neurociencias, University of the Basque Country (UPV/EHU), Leioa, Spain; Centro de Salud Mental Barakaldo, Red de Salud Mental de Bizkaia, Barakaldo, Spain.

PMID: 30625343
DOI: 10.1016/j.neuint.2019.01.004

No abstract available

Keywords: Bipolar disorder; Catechol-O-Methyltransferase (COMT); Glutamate decarboxylase 1 (GAD1); Plasma gamma-aminobutyric acid; Plasma homovanillic acid; Schizophrenia.

MeSH terms

Adult
Biomarkers / blood
Bipolar Disorder / blood*
Bipolar Disorder / genetics*
Female
Glutamate Decarboxylase / genetics*
Haplotypes / genetics
Homovanillic Acid / blood*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
gamma-Aminobutyric Acid / blood*

Substances

Biomarkers
gamma-Aminobutyric Acid
Glutamate Decarboxylase
glutamate decarboxylase 1
Homovanillic Acid