A "Connexin" Responsible for the Fatal Attraction of Cancer to Bone

Cell Metab. 2019 Jan 8;29(1):6-8. doi: 10.1016/j.cmet.2018.12.014.

Abstract

Tumor cell interactions with the bone microenvironment are vital for the establishment and progression of bone metastases. Recently in Cancer Cell, Wang et al. (2018) showed that cells of the osteoblast lineage are critical for the delivery of calcium to tumor cells through gap junctions, pointing toward potential therapies for bone metastases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Bone and Bones
  • Calcium*
  • Connexins
  • Gap Junctions
  • Humans
  • Neoplasm Micrometastasis*
  • Osteoblasts
  • Osteogenesis
  • Tumor Microenvironment

Substances

  • Connexins
  • Calcium