Prognostic value of 1p/19q chromosomal codeletion in patients with oligodendroglioma

J Pak Med Assoc. 2019 Jan;69(1):132-134.

Abstract

Oligodendrogliomas are common intra-axial primary brain tumours, and carry special significance due to several key features, which when present provide better prognosis compared to other intra-axial tumours. One of these features is presence of 1p/19q chromosomal codeletion that seems to not only be a marker of better prognosis but also signifies better response to chemotherapy. Herein the authors review the literature for evidence of the prognostic value of 1p/19q codeletion in OD.

Keywords: Glioma, Oligodendroglioma, chemotherapy..

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Brain Neoplasms* / diagnosis
  • Brain Neoplasms* / drug therapy
  • Brain Neoplasms* / genetics
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 1 / genetics*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Neurosurgical Procedures / methods*
  • Oligodendroglioma* / diagnosis
  • Oligodendroglioma* / drug therapy
  • Oligodendroglioma* / genetics
  • Prognosis

Substances

  • Antineoplastic Agents