Thiabendazole/bentonites hybrids as controlled release systems

Graycyelle R S Cavalcanti; Maria G Fonseca; Edson C da Silva Filho; Maguy Jaber

doi:10.1016/j.colsurfb.2018.12.030

Thiabendazole/bentonites hybrids as controlled release systems

Colloids Surf B Biointerfaces. 2019 Apr 1:176:249-255. doi: 10.1016/j.colsurfb.2018.12.030. Epub 2018 Dec 13.

Authors

Graycyelle R S Cavalcanti¹, Maria G Fonseca², Edson C da Silva Filho³, Maguy Jaber⁴

Affiliations

¹ Núcleo de Pesquisa e Extensão - Laboratório de Combustíveis e Materiais (NPE - LACOM), Universidade Federal da Paraíba, Cidade Universitária, s/n - Castelo Branco III, 58051-085, João Pessoa, PB, Brazil; Sorbonne Université, Laboratoire d'Archéologie Moléculaire et Structurale, CNRS UMR 8220, Tour 23, 3ème étage, couloir 23-33, BP 225, 4 place Jussieu, 75005, Paris, France.
² Núcleo de Pesquisa e Extensão - Laboratório de Combustíveis e Materiais (NPE - LACOM), Universidade Federal da Paraíba, Cidade Universitária, s/n - Castelo Branco III, 58051-085, João Pessoa, PB, Brazil. Electronic address: mgardennia@quimica.ufpb.br.
³ Interdisciplinary Laboratory of Advanced Materials, CCN, UFPI, 64049-550, Teresina, Piaui, Brazil.
⁴ Sorbonne Université, Laboratoire d'Archéologie Moléculaire et Structurale, CNRS UMR 8220, Tour 23, 3ème étage, couloir 23-33, BP 225, 4 place Jussieu, 75005, Paris, France. Electronic address: maguy.jaber@upmc.fr.

PMID: 30623812
DOI: 10.1016/j.colsurfb.2018.12.030

Abstract

Clay minerals are commonly used in pharmaceutical products as excipients and active agents. New drug vehicles based on clay minerals have been developed. In this work, sodium (BentNa), calcium (BentCa) and magnesium (BentMg) exchanged bentonites were used for the sorption of thiabendazole (TBZ), and their potential use as controlled release systems was evaluated. Pristine bentonite and exchanged bentonites were characterized by X-ray diffraction, infrared spectroscopy, thermogravimetry and transmission electron microscopy (TEM), and the influence of the different parameters such as pH, contact time and initial concentration of the drug was investigated. The maximum adsorption reached after 45 min period with 2000 mg L^-1 of thiabendazole to BentNa and after 105 min with 1300 mg L^-1 to BentCa and BentMg, respectively. The maximum adsorbed quantities of thiabendazole were 164.4; 152.3 and 133.3 mg g^-1 for BentNa, BentCa and BentMg, respectively. The emission profiles obtained for the bentonite/drug hybrids were similar when simulated body fluids were used and these emission profiles were fitted according to the Korsmeyer-Peppas kinetic model.

Keywords: Clay minerals; Clay/drugs hybrids; Drug delivery system; Thiabendazole.

MeSH terms

Adsorption
Bentonite / chemistry*
Delayed-Action Preparations / pharmacology*
Drug Liberation
Hydrogen-Ion Concentration
Kinetics
Models, Theoretical
Spectroscopy, Fourier Transform Infrared
Thiabendazole / chemistry*
Time Factors
X-Ray Diffraction

Substances

Delayed-Action Preparations
Bentonite
Thiabendazole