Assessment of medication use during pregnancy by Web-based questionnaires, pharmacy records and serum screening

Marleen M H J van Gelder; Lutea A A de Jong; Bernke Te Winkel; Erik J H Olyslager; Saskia Vorstenbosch; Eugène P van Puijenbroek; André L M Verbeek; Nel Roeleveld

doi:10.1016/j.reprotox.2019.01.002

Assessment of medication use during pregnancy by Web-based questionnaires, pharmacy records and serum screening

Reprod Toxicol. 2019 Mar:84:93-97. doi: 10.1016/j.reprotox.2019.01.002. Epub 2019 Jan 4.

Authors

Marleen M H J van Gelder¹, Lutea A A de Jong², Bernke Te Winkel³, Erik J H Olyslager⁴, Saskia Vorstenbosch⁵, Eugène P van Puijenbroek⁶, André L M Verbeek⁷, Nel Roeleveld⁸

Affiliations

¹ Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands; Radboud REshape Innovation Center, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address: marleen.vangelder@radboudumc.nl.
² Department of Pharmacy, Gelre Hospitals, P.O. Box 9014, 7300 DS, Apeldoorn, the Netherlands. Electronic address: l.van.gendt@gelre.nl.
³ Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH, 's-Hertogenbosch, the Netherlands. Electronic address: b.tewinkel@lareb.nl.
⁴ Department of Pharmacy, Gelre Hospitals, P.O. Box 9014, 7300 DS, Apeldoorn, the Netherlands. Electronic address: e.olyslager@gelre.nl.
⁵ Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH, 's-Hertogenbosch, the Netherlands. Electronic address: s.vorstenbosch@lareb.nl.
⁶ Netherlands Pharmacovigilance Centre Lareb, Goudsbloemvallei 7, 5237 MH, 's-Hertogenbosch, the Netherlands; PharmacoTherapy, -Epidemiology and -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, the Netherlands. Electronic address: e.vanpuijenbroek@lareb.nl.
⁷ Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address: andre.verbeek@radboudumc.nl.
⁸ Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands. Electronic address: nel.roeleveld@radboudumc.nl.

PMID: 30615926
DOI: 10.1016/j.reprotox.2019.01.002

Abstract

Objective: To compare assessment of early pregnancy medication exposure using three methods of data collection.

Methods: Serum samples were obtained from 752 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study before gestational week 17. For 52 women using medication at the date of blood sampling according to Web-based questionnaires or pharmacy records, we analysed serum samples using untargeted liquid chromatography time-of-flight spectrometry.

Results: Medication was detected in 18 serum samples (35%). Medications taken orally for chronic conditions reported in the questionnaire were detected in serum and vice versa. Pharmacy records did not identify additional exposed women, but missed exposure in 5 women mainly due to unavailability. We observed substantial discordance between the three methods for inhaled medication, dermatological preparations, and medications for short-term use, which went often undetected in serum.

Conclusions: It remains challenging to assess medication use in large-scale studies as no 'gold standard' is currently available.

Keywords: Drug monitoring; LC-TOF-MS; PRIDE Study; Pharmacy records; Pregnancy; Questionnaires.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Drug Monitoring
Drug Utilization*
Female
Humans
Internet
Medical Records
Pharmaceutical Preparations / blood*
Pharmacies
Pregnancy / blood*
Self Report
Surveys and Questionnaires

Substances

Pharmaceutical Preparations