Case report of Zika virus during controlled ovarian hyperstimulation: results from follicular fluid, cumulus cells and oocytes

JBRA Assist Reprod. 2019 Apr 30;23(2):172-174. doi: 10.5935/1518-0557.20180081.

Abstract

We describe a case of a 37-year-old female, indicated for in vitro fertilisation. She developed skin rash on her trunk and limbs, during the treatment. RT-PCR results were positive in her blood and negative in her husband's blood and semen. Oocyte aspiration was performed, retrieving 7 oocytes, follicular fluid, and cumulus cells. RT-PCR results for the follicular fluid and cumulus cells were negative for ZIKV, and positive for only 2 oocytes. This is the first report in the literature analysing ZIKV in the follicular fluid, cumulus cells, and oocytes, and will contribute to the understanding of ZIKV infection and transmission.

Keywords: RT-PCR; Zika virus; follicular fluid; in vitro fertilisation; oocytes.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Oocytes / virology*
  • Ovarian Follicle / virology*
  • Ovulation Induction*
  • RNA, Viral / genetics
  • Real-Time Polymerase Chain Reaction
  • Semen / virology
  • Zika Virus / genetics*
  • Zika Virus Infection* / diagnosis
  • Zika Virus Infection* / transmission
  • Zika Virus Infection* / virology

Substances

  • RNA, Viral