Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum

Jia-Min Feng; Min Li; Jin-Lian Zhao; Xiao-Na Jia; Ji-Mei Liu; Min Zhang; Ri-Dao Chen; Ke-Bo Xie; Da-Wei Chen; Hai-Bo Yu; Jun-Gui Dai

doi:10.1080/10286020.2018.1551372

Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum

J Asian Nat Prod Res. 2019 Sep;21(9):887-894. doi: 10.1080/10286020.2018.1551372. Epub 2019 Jan 5.

Authors

Jia-Min Feng^{1

2}, Min Li¹, Jin-Lian Zhao^{1

2}, Xiao-Na Jia^{1

2}, Ji-Mei Liu^{1

2}, Min Zhang^{1

2}, Ri-Dao Chen^{1

2}, Ke-Bo Xie^{1

2}, Da-Wei Chen^{1

2}, Hai-Bo Yu¹, Jun-Gui Dai^{1

2}

Affiliations

¹ a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
² b Key Laboratory of Biosynthesis of Natural Products of National Health Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.

PMID: 30614271
DOI: 10.1080/10286020.2018.1551372

Abstract

Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam (4), were isolated from Stachybotrys chartarum CGMCC 3.5365. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 1 and 2 showed inhibitory effect towards potassium channel Kv1.3 with IC₅₀ values of 13.4 and 10.9 μM, respectively.

Keywords: Phenylspirodrimanes derivatives; potassium channel Kv1.3.

MeSH terms

Animals
CHO Cells
Cell Line
Cricetinae
Cricetulus
Kv1.3 Potassium Channel / antagonists & inhibitors*
Spiro Compounds / chemistry*
Stachybotrys / chemistry*

Substances

Kv1.3 Potassium Channel
Spiro Compounds