Physiologically based toxicokinetics (PBTK) models for pharmaceuticals and personal care products in wild common carp (Cyprinus carpio)

Abstract

Pharmaceutical and personal care products (PPCPs) are regarded as "pseudo-persistent" pollutants due to their being continuously loaded into the aquatic environment. Physiologically based toxicokinetics (PBTK) models that can quantitatively describe absorption, distribution, metabolism and excretion processes of chemicals in biota are of importance to predict internal exposure (e.g. doses at specific target tissues/organs) from external exposure concentrations. In this study, PBTK models with up to six compartments including brain, liver, kidney, gills, richly perfused tissues and poorly perfused tissues, were developed for predicting internal distribution of 10 PPCPs in wild common carp (Cyprinus carpio). The PBTK predicted concentrations were close to the measured ones, with deviations less than 1 log unit for most of PPCPs. Sensitivity analysis showed that various partition coefficients of the chemicals exerted significant influence on model outputs.

Keywords: Common carp; Gill accumulation; Hepatic metabolism; Internal exposure; Pharmaceutical and personal care products; Physiologically based toxicokinetics.