The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish

Rafael Genario; Ana C V V Giacomini; Konstantin A Demin; Bruna E Dos Santos; Natalia I Marchiori; Angrey D Volgin; Alim Bashirzade; Tamara G Amstislavskaya; Murilo S de Abreu; Allan V Kalueff

doi:10.1016/j.neubiorev.2018.12.025

The evolutionarily conserved role of melatonin in CNS disorders and behavioral regulation: Translational lessons from zebrafish

Neurosci Biobehav Rev. 2019 Apr:99:117-127. doi: 10.1016/j.neubiorev.2018.12.025. Epub 2019 Jan 3.

Affiliations

¹ Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
² Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.
³ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁴ Laboratory of Translational Biopsychiatry, Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia.
⁵ Laboratory of Translational Biopsychiatry, Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia.
⁶ Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA. Electronic address: abreu_murilo@hotmail.com.
⁷ School of Pharmacy, Southwest University, Chongqing, China; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Laboratory of Translational Biopsychiatry, Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Granov's Russian Scientific Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address: avkalueff@gmail.com.

PMID: 30611799
DOI: 10.1016/j.neubiorev.2018.12.025

Abstract

Melatonin is an important hormone regulating circadian rhythm, neuroprotection and neuroimmune processes. However, its exact physiological roles in brain mechanisms remain poorly understood. Here, we summarize the mounting evidence implicating melatonin in brain disorders and behavior, based on clinical and experimental studies in-vivo. In addition to rodent models, the zebrafish (Danio rerio) is becoming increasingly utilized in biomedical and neuroscience research. Here, we discuss melatonin neurobiology of zebrafish, and parallel these findings with clinical and rodent data. We also discuss the genomic effects of melatonin in zebrafish, and emphasize the growing utility of zebrafish models to study melatonin neurobiology and drug discovery.

Keywords: Animal model; Behavioral regulation; CNS; Genetic model; Melatonin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Behavior, Animal / drug effects*
Brain / drug effects*
Brain / physiology
Central Nervous System Diseases / drug therapy*
Disease Models, Animal
Humans
Melatonin / pharmacology*
Zebrafish / physiology

Substances

Melatonin