Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial

Anderson Rech; Cíntia Ehlers Botton; Pedro Lopez; André Quincozes-Santos; Daniel Umpierre; Ronei Silveira Pinto

doi:10.1016/j.exger.2019.01.003

Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial

Exp Gerontol. 2019 Apr:118:19-25. doi: 10.1016/j.exger.2019.01.003. Epub 2019 Jan 3.

Authors

Anderson Rech¹, Cíntia Ehlers Botton², Pedro Lopez³, André Quincozes-Santos⁴, Daniel Umpierre⁵, Ronei Silveira Pinto³

Affiliations

¹ Life Sciences Center, Universidade de Caxias do Sul, Caxias do Sul, RS 95070-560, Brazil; Exercise Research Laboratory, School of Physical Education, Phisiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90690-200, Brazil. Electronic address: arech16@ucs.br.
² Exercise Research Laboratory, School of Physical Education, Phisiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90690-200, Brazil; Hospital de Clínicas de Porto Alegre, National Institute of Science and Technology for Health Technology Assessment (IATS), Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-007, Brazil.
³ Exercise Research Laboratory, School of Physical Education, Phisiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90690-200, Brazil.
⁴ Departamento de Bioquímica, Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Bairro Santa Cecília, Porto Alegre, RS 90035-003, Brazil.
⁵ Hospital de Clínicas de Porto Alegre, National Institute of Science and Technology for Health Technology Assessment (IATS), Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-007, Brazil.

PMID: 30611727
DOI: 10.1016/j.exger.2019.01.003

Abstract

Purpose: To evaluate the effects of 12-weeks of strength training on endothelial function and inflammatory markers in elderly individuals with T2DM.

Methods: Forty-four elderly patients with T2DM were screened for participation. After completion of the baseline assessment, participants were randomly assigned to either the resistance training group (RT) or an active control group (AC). Inflammatory (TNF-α, IL-6, IL-1β, IL-10 and CRP) and blood lipid profiles, glycated hemoglobin, basal artery diameter and flow mediated dilation were evaluated before and after the intervention. Comparisons between groups were obtained from the generalized estimation equation and all tests were two-tailed and the alpha level for significance set at 0.05.

Results: TNF-α and IL-1β were decreased in both groups, while no interactions were found for flow mediated dilation and basal artery diameter. No significant differences were found for blood lipid profile and glycated hemoglobin for both groups after the intervention period.

Conclusions: No significant changes were found between the RT and AC groups, regarding inflammatory profile and endothelial function, which does not prove the superiority of this intervention model in the studied period.

Keywords: Cytokines; Physical exercise; Strength training; Vascular health.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Biomarkers / blood
C-Reactive Protein / analysis
Diabetes Mellitus, Type 2 / immunology
Diabetes Mellitus, Type 2 / physiopathology*
Endothelium, Vascular / physiopathology*
Female
Humans
Inflammation / prevention & control*
Interleukin-10 / blood
Lipids / blood
Male
Middle Aged
Prospective Studies
Resistance Training*
Tumor Necrosis Factor-alpha / blood

Substances

Biomarkers
IL10 protein, human
Lipids
Tumor Necrosis Factor-alpha
Interleukin-10
C-Reactive Protein