FBXO38 Drives PD-1 to Destruction

Taryn M Serman; Michaela U Gack

doi:10.1016/j.it.2018.12.005

FBXO38 Drives PD-1 to Destruction

Trends Immunol. 2019 Feb;40(2):81-83. doi: 10.1016/j.it.2018.12.005. Epub 2019 Jan 1.

Authors

Taryn M Serman¹, Michaela U Gack²

Affiliations

¹ Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
² Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA. Electronic address: mgack@uchicago.edu.

PMID: 30609969
DOI: 10.1016/j.it.2018.12.005

Abstract

Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote tumor progression. A recent study (Nature 2018;564:130-135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.

Publication types

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MeSH terms

Humans
Immunotherapy
Neoplasms*
Programmed Cell Death 1 Receptor / genetics*
T-Lymphocytes
Ubiquitination

Substances

Programmed Cell Death 1 Receptor