Metal coordination-functionalized Au-Ag bimetal SERS nanoprobe for sensitive detection of glutathione

Pan Li; Meihong Ge; Liangbao Yang; Jinhuai Liu

doi:10.1039/c8an02206b

Metal coordination-functionalized Au-Ag bimetal SERS nanoprobe for sensitive detection of glutathione

Analyst. 2019 Jan 21;144(2):421-425. doi: 10.1039/c8an02206b. Epub 2019 Jan 4.

Authors

Pan Li¹, Meihong Ge², Liangbao Yang², Jinhuai Liu¹

Affiliations

¹ Institute of Intelligent Machines, Chinese Academy of Sciences, Anhui, Hefei 230031, China. lbyang@iim.ac.cn.
² Institute of Intelligent Machines, Chinese Academy of Sciences, Anhui, Hefei 230031, China. lbyang@iim.ac.cn and Department of Chemistry, University of Science & Technology of China, Hefei 230026, Anhui, China.

PMID: 30608064
DOI: 10.1039/c8an02206b

Abstract

We demonstrated a surface-enhanced Raman spectroscopy (SERS) nanoprobe, neocuproine-Cu (Nc-Cu^II)-functionalized Au-Ag "nanobowls" (Au-Ag NBs/Nc-Cu^II), for detection of glutathione (GSH). Detection was accomplished with alternation of SERS spectra from Nc-Cu^II into Nc-Cu^I resulting from the reaction of GSH with Nc-Cu^II on Au-Ag NBs. This nanoprobe exhibited high selectivity and sensitivity (μM) towards GSH.

MeSH terms

Glutathione / analysis*
Glutathione / chemistry*
Gold / chemistry*
Limit of Detection*
Nanostructures / chemistry*
Silver / chemistry*
Spectrum Analysis, Raman / methods*

Substances

Silver
Gold
Glutathione