Abstract
This article reviews recent work in applying neutron and X-ray scattering towards the elucidation of the molecular mechanisms of volatile anesthetics. Experimental results on domain mixing in ternary lipid mixtures, and the influence of volatile anesthetics and hydrostatic pressure are placed in the contexts of ion-channel function and receptor trafficking at the postsynaptic density.
Keywords:
anesthesia; lipid rafts; membranes; neutron scattering; synaptic plasticity.
MeSH terms
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Anesthetics / pharmacology*
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Animals
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Humans
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Hydrostatic Pressure
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Ion Channels / chemistry
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Ion Channels / metabolism
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Membrane Lipids / chemistry
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Membrane Lipids / metabolism*
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Membrane Microdomains / chemistry
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Membrane Microdomains / drug effects
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Membrane Microdomains / metabolism
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Neuronal Plasticity / drug effects
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Neutron Diffraction / methods*
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Post-Synaptic Density / chemistry
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Post-Synaptic Density / drug effects*
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Post-Synaptic Density / metabolism
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / metabolism
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Scattering, Small Angle
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Volatile Organic Compounds / pharmacology*
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X-Ray Diffraction / methods*
Substances
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Anesthetics
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Ion Channels
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Membrane Lipids
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Membrane Proteins
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Receptors, Cell Surface
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Volatile Organic Compounds
Grants and funding
This work was funded by National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development grant .