A computational model of ureteral peristalsis and an investigation into ureteral reflux

Biomed Eng Lett. 2017 Nov 18;8(1):117-125. doi: 10.1007/s13534-017-0053-0. eCollection 2018 Feb.

Abstract

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes-Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis.

Keywords: CFD; PUJ; Reflux; Ureter; VUJ; VUR.