Retinal pigment epithelial tears

Abstract

A retinal pigment epithelial (RPE) tear is a well-known complication of retinal pigment epithelial detachments (PED) and may cause a significant visual impairment. The most common cause is a vascularized PED in patients with exudative age-related macular degeneration (AMD). The development of diagnostic imaging techniques brings us closer to the etiology and pathophysiological mechanisms of this entity, offering us new strategies for treatment and follow-up. The advent of intravitreal antiangiogenic treatment (anti-VEGF) has led to an increase in the number of reported cases of RPE tears, which are an important vision-limiting factor during treatment. However, RPE tears may occur spontaneously or as a consequence of thermal laser treatment, photodynamic therapy or anti-VEGF therapy. It is accepted that the mechanism of RPE tears is multifactorial. The optimization of the functional outcome of this complication has been described with continuous treatment with antiangiogenic drugs. The goal of the present review is to evaluate the incidence, risk factors and treatment of RPE tears.

Keywords: Age-related macular degeneration; Anti-angiogenics; Anti-angiogénique; Déchirure de l’épithélium pigmentaire rétinien (EPR); Dégénérescence maculaire liée à l’âge; Détachements épithéliaux pigmentaires rétiniens; Facteurs de risque pour déchirures de l’épithélium pigmentaire rétinien; Retinal pigment epithelial (RPE) tear; Retinal pigment epithelial detachments; Risk factors for retinal pigment epithelial tear.