Effectiveness of clobazam on perception, creativity, intelligence, selective and visual memory

Pak J Pharm Sci. 2018 Nov;31(6 (Supplementary):2715-2718.

Abstract

Clobazam belongs to benzodiazepine class and is preferably used against anti-epileptic disorders. However, when used in reduced doses, its ability for improving cognitive functions becomes explicitly evident. This study objectively undertook the task of using the reduced doses of clobazam for proving potentials effects on cognitive functions. The drug, clobazam was administered in "active group" which contained 15 young healthy volunteers. The "placebo group" also entailed 15 subjects and each was administered with placebo drug. The controlled group‟ also included 15 subjects. All these 45 young healthy subjects were subjected to tests for perceptual learning, creativity, selective memory, visual memory and intelligence. Results clearly demonstrated significant impact of clobazam at the dose of 5mg/day on perceptual learning (P=0.0380), creativity (P=0.0787), memory function (P=0.4920), visual memory (P=0.4816) and intelligence of the subject (P=0.4920). The outcomes highlighted in the studies reviled the positive effects of clobazam when used at reduced doses.

MeSH terms

  • Adult
  • Anti-Anxiety Agents / pharmacology*
  • Clobazam / pharmacology*
  • Creativity*
  • Female
  • Humans
  • Intelligence / drug effects*
  • Intelligence / physiology
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Psychomotor Performance / drug effects
  • Psychomotor Performance / physiology
  • Random Allocation
  • Visual Perception / drug effects*
  • Visual Perception / physiology
  • Young Adult

Substances

  • Anti-Anxiety Agents
  • Clobazam