Tackling Cancer with Yeast-Based Technologies

Trends Biotechnol. 2019 Jun;37(6):592-603. doi: 10.1016/j.tibtech.2018.11.013. Epub 2018 Dec 22.

Abstract

The ability to precisely engineer yeast, coupled with its genetic and metabolic similarity to tumor cells, has enabled researchers to use this organism in cancer research. Here we review advances that leveraged yeast as a model organism for studying cancer biology, including the investigation of tumorigenic mechanisms, development of advanced technologies for drug discovery, production of anticancer drugs on an industrial scale, and delivering the next generation of immunotherapies.

Keywords: CRISPR; SGA; cancer vaccines; humanized antibody; immunotherapy; metabolic engineering.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents* / metabolism
  • Antineoplastic Agents* / pharmacology
  • Bioengineering*
  • Biomedical Research
  • Humans
  • Mice
  • Models, Biological*
  • Neoplasms* / genetics
  • Neoplasms* / metabolism
  • Neoplasms* / therapy
  • Saccharomyces cerevisiae* / drug effects
  • Saccharomyces cerevisiae* / genetics
  • Saccharomyces cerevisiae* / metabolism

Substances

  • Antineoplastic Agents