Abstract
Six-week-old male KK-Ay mice received drinking water with S-adenosylmethionine (SAM), α-glycerophosphocholine (GPC), or SAM+GPC for 10 weeks. The serum glucose of SAM+GPC at 15 weeks old, total cholesterol of GPC at 12 weeks old, and triglyceride of GPC at 15 weeks old and of SAM at 16 weeks old were reduced. SAM+GPC reduced serum leptin and food intake. Abbreviations: SAM: S-adenosylmethionine; GPC: α-glycerophosphocholine.
Keywords:
-adenosylmethionine; KK-A mouse; leptin; α-glycerophosphocholine.
MeSH terms
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Administration, Oral
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Animals
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Blood Glucose / drug effects
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Blood Glucose / metabolism
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Body Weight / drug effects
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Cholesterol / blood
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Experimental / physiopathology
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Disease Models, Animal
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Drinking Water
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Drug Combinations
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Eating / drug effects
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Glycerylphosphorylcholine / pharmacology*
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Hyperglycemia / blood
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Hyperglycemia / drug therapy*
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Hyperglycemia / physiopathology
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Hyperinsulinism / blood
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Hyperinsulinism / drug therapy*
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Hyperinsulinism / physiopathology
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Hyperlipidemias / blood
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Hyperlipidemias / drug therapy*
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Hyperlipidemias / physiopathology
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Hypoglycemic Agents / pharmacology*
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Leptin / blood
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Male
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Mice
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Mice, Transgenic
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Obesity / blood
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Obesity / drug therapy*
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Obesity / physiopathology
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S-Adenosylmethionine / pharmacology*
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Triglycerides / blood
Substances
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Blood Glucose
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Drinking Water
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Drug Combinations
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Hypoglycemic Agents
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Leptin
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Triglycerides
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Glycerylphosphorylcholine
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S-Adenosylmethionine
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Cholesterol