A new polyhydroxylated oleanane triterpenoid from the roots of Rhodomyrtus tomentosa

Abstract

A new oleanane triterpenoid, 2α,3β,6β,23,29-pentahydroxyolean-12-en-28- oic acid (1), was isolated from the roots of Rhodomyrtus tomentosa, together with four known oleanane triterpenoids (2-5) and two known ursane triterpenoids (6-7). The structure of compound 1 was determined by extensive NMR and HR-ESI-MS data analysis. Compounds 4-5 showed cytotoxicity against PC12 cell lines at a concentration of 50 μM, and compound 1 exhibited moderate neuroprotective activity against corticosterone induced PC12 cell death at the same concentration.

Keywords: Neuroprotective activity; Oleanane triterpenoid; Rhodomyrtus tomentosa.