Abstract
A new flavanone glycoside, (2S)-dihydrooroxylin A 7-O-[β-D-apiosyl(1→2)]-β-D-glucoside (1), and four known compounds (2-5) were isolated from Tournefortia sibirica L. The chemical structures of these compounds were determined by 1 D and 2 D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. These five compounds (1-5) were isolated from the family Boraginaceae for the first time. Anti-inflammatory effects of compounds (1-5) were evaluated in terms of inhibition of production of NO, TNF-α, and IL-6 in LPS-induced RAW 264.7 cells.
Keywords:
L.; Boraginaceae; flavanone glycoside.
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Boraginaceae / chemistry*
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Flavanones / isolation & purification*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Interleukin-6 / antagonists & inhibitors
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Interleukin-6 / biosynthesis
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Plant Extracts / chemistry
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RAW 264.7 Cells
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Spectrum Analysis
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Anti-Inflammatory Agents
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Flavanones
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Flavonoids
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Glycosides
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Interleukin-6
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Plant Extracts
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Tumor Necrosis Factor-alpha
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dihydrooroxylin
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interleukin-6, mouse
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Nitric Oxide