IgA nephropathy with diffuse alveolar haemorrhage

BMJ Case Rep. 2018 Dec 22;11(1):e227382. doi: 10.1136/bcr-2018-227382.

Abstract

Immunoglobulin (Ig)A nephropathy is the most common cause of primary glomerulonephritis worldwide. While IgA nephropathy has been associated with a variety of other diseases, pulmonary complications are extremely rare. A 58-year-old man presented with a 2-week history of fever and exertional dyspnoea. A chest imaging revealed bilateral consolidation predominantly in upper lungs. Laboratory findings showed elevated serum creatinine with proteinuria and haematuria. Flexible bronchoscopy revealed diffuse alveolar haemorrhage, and IgA nephropathy was confirmed on a renal biopsy. He received prednisone with good effect. This case highlights the need to consider IgA nephropathy in the differential diagnosis of pulmonary renal syndrome.

Keywords: acute renal failure; respiratory medicine.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Glomerulonephritis, IGA / complications*
  • Glomerulonephritis, IGA / pathology
  • Hemorrhage / immunology*
  • Hemorrhage / pathology
  • Humans
  • Kidney / immunology
  • Kidney / pathology
  • Lung Diseases / immunology*
  • Lung Diseases / pathology
  • Male
  • Middle Aged
  • Prednisone / therapeutic use
  • Pulmonary Alveoli / immunology
  • Pulmonary Alveoli / pathology

Substances

  • Prednisone