IL-17 production by NKG2D-expressing CD56+ T cells in type 2 diabetes

Abstract

T cells expressing CD56 (identified as CD3+CD56+) play a potential role in activation or regulation of other immune cells by secreting various cytokines. We hypothesized that these cells expressing the natural group 2, member D (NKG2D) could produce high levels of interleukin (IL)-17 in type 2 diabetes (T2D). CD56 + T cells expressing NKG2D of T2D patients, particularly in poor glycemic control (PC) predominantly produced higher IL-17 compared to the NKG2D negative population. IL-17 production of CD56 + T cells with NKG2D + was positively correlated with the level of HbA1c (N = 22, R² = 0.120 and P = 0.044). Interestingly, CD56+ T cells with NKG2D^Hi of T2D patients had significantly higher IL-17 production than those of CD56 + T cells with NKG2D^Low (P = 0.027) and showed statistically significant with P-value < 0.001 compared to CD56 + T cells with NKG2D^Hi of non-diabetic individuals (ND). In summary, CD56 + T cells expressing NKG2D, especially in the NKG2D^Hi population may be involved in pathogenesis and severity of T2D via IL-17.

Keywords: CD56+ T cells; HbA1c; IL-17; NKG2D; Type 2 diabetes.