Myocardial Oxygen Consumption and Efficiency in Patients With Cardiac Amyloidosis

Abstract

Background This study evaluated myocardial oxygen consumption (MVO₂) and myocardial external efficiency (MEE) in patients with cardiac amyloidosis (CA). Furthermore, we compared MEE and MVO₂ in subjects with light chain amyloidosis versus transthyretin (ATTR) amyloidosis. Methods and Results The study population comprised 40 subjects: 25 patients with confirmed CA and 15 control subjects. All subjects underwent an ¹¹C-acetate positron emission tomography. Furthermore, the CA patients underwent comprehensive echocardiography and right heart catheterization during a symptom-limited, semi-supine exercise test. MEE was calculated from ¹¹C-acetate positron emission tomography as the ratio of left ventricular (LV) stroke work and the energy equivalent of MVO₂. Myocardial work efficiency was calculated as echocardiography-derived work pressure product divided by three-dimensional LV mass. CA patients had significantly lower LV-ejection fraction (54±13% versus 63±4%, P<0.05) and LV-global longitudinal strain (LVGLS) (12±4% versus 19±2%, P<0.0001) and a more restrictive filling pattern (E/e'-ratio 18 [12-25] versus 8 [7-9], P<0.0001) than controls. MEE was severely reduced (13±5% versus 22±5%, P<0.0001) whereas total MVO₂ was higher (18±6 mL/min versus 13±3 mL/min, P<0.01) in CA patients than controls. MEE decreased with increasing New York Heart Association symptom burden ( P<0.0001). We found a good relationship between MEE and peak exercise systolic performance (LVGLS: R²=0.60, P<0.0001; myocardial work efficiency: R²=0.48, P<0.0001; cardiac index: R²=0.52, P<0.0001) and between MEE and myocardial blood flow ( R²=0.44, P<0.0001). Conclusion Myocardial oxidative metabolism is disturbed in CA patients with increased total MVO₂ and reduced MEE. MEE correlated significantly with echocardiographic derived systolic parameters such as myocardial work efficiency and LVGLS that might be used as surrogate MEE markers.

Keywords: amyloid; efficiency measures; exercise physiology; myocardial metabolism; myocardial oxygen consumption; positron emission tomography; speckle tracking echocardiography; stress echocardiography.