Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders

Zheng Wang; Wei Hu; Chenxi Lu; Zhiqiang Ma; Shuai Jiang; Chunhu Gu; Darío Acuña-Castroviejo; Yang Yang

doi:10.1161/ATVBAHA.118.311916

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders

Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2765-2779. doi: 10.1161/ATVBAHA.118.311916.

Authors

Zheng Wang^{1

2}, Wei Hu³, Chenxi Lu¹, Zhiqiang Ma⁴, Shuai Jiang⁵, Chunhu Gu⁶, Darío Acuña-Castroviejo⁷, Yang Yang¹

Affiliations

¹ From the Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Taibai, Xi'an, China (Z.W., C.L., Y.Y.).
² Department of Cardiothoracic Surgery, Wuhan General Hospital of The People's Liberation Army, China (Z.W.).
³ Department of Immunology (W.H.), The Fourth Military Medical University, Xi'an, China.
⁴ Department of Thoracic Surgery, Tangdu Hospital (Z.M.), The Fourth Military Medical University, Xi'an, China.
⁵ Department of Aerospace Medicine (S.J.), The Fourth Military Medical University, Xi'an, China.
⁶ Department of Cardiovascular Surgery, Xijing Hospital (C.G.), The Fourth Military Medical University, Xi'an, China.
⁷ Biomedical Research Center, Health Sciences Technology Park, University of Granada, Spain (D.A.-C.).

PMID: 30571177
DOI: 10.1161/ATVBAHA.118.311916

Abstract

Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome is the best-characterized inflammasome. Recent evidence has indicated the importance of the NLRP3 inflammasome in the pathophysiology of cardiovascular disorders. To further understand the roles of the NLRP3 inflammasome in the cardiovascular system, we provide a comprehensive overview and discuss the remaining questions. First, a summary of NLRP3 inflammasome in the cardiovascular system is introduced. Then, the associations between NLRP3 inflammasome and cardiovascular disorders are presented. Finally, we discuss existing problems and potential directions with this issue. The information compiled here summarizes recent progress, thus potentially aiding in the understanding of the NLRP3 inflammasome in cardiovascular disorders, designing experimental and clinical research about the NLRP3 inflammasome, and promoting therapeutics for cardiovascular disorders.

Keywords: atherosclerosis; cardiovascular diseases; inflammation; interleukins; myocardial ischemia.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Inflammatory Agents / therapeutic use*
Cardiovascular Agents / therapeutic use*
Cardiovascular Diseases / drug therapy*
Cardiovascular Diseases / immunology
Cardiovascular Diseases / metabolism
Cardiovascular Diseases / physiopathology
Humans
Immunity, Innate / drug effects
Inflammasomes / antagonists & inhibitors*
Inflammasomes / immunology
Inflammasomes / metabolism
Molecular Targeted Therapy
NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors*
NLR Family, Pyrin Domain-Containing 3 Protein / immunology
NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
Signal Transduction / drug effects

Substances

Anti-Inflammatory Agents
Cardiovascular Agents
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human