Choroidal melanoma masquerading as orbital cellulitis

BMJ Case Rep. 2018 Dec 9;11(1):e227486. doi: 10.1136/bcr-2018-227486.

Abstract

Orbital cellulitis is the most common subset of orbital inflammatory disease. We describe a patient with necrotic choroidal melanoma who presented with orbital cellulitis. MRI revealed a mass lesion suggesting intraocular melanoma with no extrascleral extension. There was no metastasis on positron emission tomography-CT scan. Enucleation with orbital implant was performed. Histopathological analysis of the specimen revealed intraocular necrotic melanoma with very few recognisable melanoma cells. The necrotic subtype is more commonly associated with extrascleral extension, distant metastasis and poorer prognosis than other melanoma types. Sterile orbital cellulitis may rarely be a manifestation of ocular tumours in adults, and a high index of suspicion should be maintained to rule out the same.

Keywords: cancer intervention; ultrasonography.

Publication types

  • Case Reports

MeSH terms

  • Choroid Neoplasms / pathology*
  • Choroid Neoplasms / surgery
  • Diagnosis, Differential
  • Eye Enucleation
  • Eye Neoplasms / pathology*
  • Eye Neoplasms / surgery
  • Humans
  • Intraocular Pressure
  • Male
  • Melanoma / pathology*
  • Melanoma / surgery
  • Middle Aged
  • Orbital Cellulitis / etiology
  • Orbital Cellulitis / pathology*
  • Orbital Cellulitis / surgery
  • Treatment Outcome
  • Uveal Neoplasms / pathology*
  • Uveal Neoplasms / surgery

Supplementary concepts

  • Uveal melanoma