Make (No) Bones about Butyrate

Christina Begka; Benjamin J Marsland

doi:10.1016/j.immuni.2018.12.005

Make (No) Bones about Butyrate

Immunity. 2018 Dec 18;49(6):994-996. doi: 10.1016/j.immuni.2018.12.005.

Authors

Christina Begka¹, Benjamin J Marsland²

Affiliations

¹ Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
² Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address: benjamin.marsland@monash.edu.

PMID: 30566888
DOI: 10.1016/j.immuni.2018.12.005

Abstract

In this issue of Immunity, Tyagi et al. (2018) report that the microbial metabolite butyrate orchestrates the interplay between regulatory T cells and CD8⁺ T cells, increasing Wnt signaling, and promoting bone formation in young mice.

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MeSH terms

Animals
Butyrates*
CD8-Positive T-Lymphocytes
Mice
Osteogenesis
Signal Transduction
T-Lymphocytes, Regulatory*
Wnt Proteins

Substances

Butyrates
Wnt Proteins
Wnt10b protein, mouse