CD44 Orchestrates Metastatic Teamwork

Christine L Chaffer; Jacky G Goetz

doi:10.1016/j.devcel.2018.11.038

CD44 Orchestrates Metastatic Teamwork

Dev Cell. 2018 Dec 17;47(6):691-693. doi: 10.1016/j.devcel.2018.11.038.

Authors

Christine L Chaffer¹, Jacky G Goetz²

Affiliations

¹ The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Australia. Electronic address: c.chaffer@garvan.org.au.
² INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address: jacky.goetz@inserm.fr.

PMID: 30562512
DOI: 10.1016/j.devcel.2018.11.038

Abstract

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential.

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MeSH terms

Breast Neoplasms*
Cell Aggregation
Humans
Hyaluronan Receptors
Neoplastic Stem Cells

Substances

CD44 protein, human
Hyaluronan Receptors