Targeting Hedgehog pathway in pediatric acute myeloid leukemia: challenges and opportunities

Expert Opin Ther Targets. 2019 Feb;23(2):87-91. doi: 10.1080/14728222.2019.1559822. Epub 2018 Dec 24.

Authors

Andrea Pession¹, Annalisa Lonetti¹, Salvatore Bertuccio¹, Franco Locatelli², Riccardo Masetti¹

Affiliations

¹ a Department of Pediatrics, "Lalla Seràgnoli", Hematology-Oncology Unit , University of Bologna , Bologna , Italy.
² b Department of Pediatric Hematology-Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù , Sapienza University , Rome , Italy.

PMID: 30556755
DOI: 10.1080/14728222.2019.1559822

No abstract available

Keywords: Hedgehog pathway; pediatric acute myeloid leukemia; refractory acute myeloid leukemia; target therapy.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Child
Hedgehog Proteins / antagonists & inhibitors*
Hedgehog Proteins / metabolism
Humans
Leukemia, Myeloid, Acute / drug therapy*
Leukemia, Myeloid, Acute / pathology

Substances

Antineoplastic Agents
Hedgehog Proteins