Abstract
The membrane pore-forming α-toxin is an important virulence factor of Staphylococcus aureus. Target cells can remove pores from their surface, but recent work shows that α-toxin may undermine this self-defense by clinging to epithelial cell junctions. The findings could lead to the development of novel remedies against S. aureus infections.
Keywords:
ADAM10; PLEKHA7; S. aureus α-toxin; adherens junctions; macropinocytosis; pore-forming toxin.
Copyright © 2018 Elsevier Ltd. All rights reserved.
MeSH terms
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ADAM10 Protein / drug effects
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Adherens Junctions / drug effects
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Animals
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Bacterial Toxins / toxicity*
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Carrier Proteins / drug effects
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Cell Line
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Epithelial Cells
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Hemolysin Proteins / toxicity*
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Humans
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Membrane Proteins / drug effects
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Pinocytosis / drug effects
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Staphylococcal Infections / metabolism*
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Staphylococcal Infections / therapy
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Staphylococcus aureus / pathogenicity*
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Virulence Factors
Substances
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Bacterial Toxins
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Carrier Proteins
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Hemolysin Proteins
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Membrane Proteins
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PLEKHA7 protein, human
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Virulence Factors
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staphylococcal alpha-toxin
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ADAM10 Protein