Pharmacologically evoked apnoeas. Receptors and nervous pathways involved

Life Sci. 2019 Jan 15:217:237-242. doi: 10.1016/j.lfs.2018.12.021. Epub 2018 Dec 13.

Abstract

This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT1A serotonin receptors in overcoming opioid-induced respiratory inhibition.

Keywords: 5-HT(1A) receptors; 5-HT(3) receptors; Apnoea; TRPV1 receptors; Vagus nerve; μ receptors.

Publication types

  • Review

MeSH terms

  • Animals
  • Apnea / chemically induced*
  • Apnea / etiology
  • Apnea / metabolism
  • Apnea / physiopathology
  • Humans
  • Incidence
  • Neural Pathways / drug effects*
  • Neural Pathways / metabolism
  • Neural Pathways / physiopathology
  • Receptor, Serotonin, 5-HT1A / metabolism
  • Receptors, Opioid, mu / metabolism
  • Receptors, Serotonin, 5-HT3 / metabolism
  • Respiration / drug effects
  • TRPV Cation Channels / metabolism
  • Vagus Nerve / drug effects*
  • Vagus Nerve / metabolism
  • Vagus Nerve / physiopathology

Substances

  • Receptors, Opioid, mu
  • Receptors, Serotonin, 5-HT3
  • TRPV Cation Channels
  • TRPV1 protein, human
  • Receptor, Serotonin, 5-HT1A