Abstract
This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT1A serotonin receptors in overcoming opioid-induced respiratory inhibition.
Keywords:
5-HT(1A) receptors; 5-HT(3) receptors; Apnoea; TRPV1 receptors; Vagus nerve; μ receptors.
Copyright © 2018 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Apnea / chemically induced*
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Apnea / etiology
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Apnea / metabolism
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Apnea / physiopathology
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Humans
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Incidence
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Neural Pathways / drug effects*
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Neural Pathways / metabolism
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Neural Pathways / physiopathology
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Receptor, Serotonin, 5-HT1A / metabolism
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Receptors, Opioid, mu / metabolism
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Receptors, Serotonin, 5-HT3 / metabolism
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Respiration / drug effects
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TRPV Cation Channels / metabolism
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Vagus Nerve / drug effects*
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Vagus Nerve / metabolism
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Vagus Nerve / physiopathology
Substances
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Receptors, Opioid, mu
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Receptors, Serotonin, 5-HT3
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TRPV Cation Channels
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TRPV1 protein, human
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Receptor, Serotonin, 5-HT1A