LncRNAs in ovarian cancer

Jin-Yan Wang; Ai-Qing Lu; Li-Juan Chen

doi:10.1016/j.cca.2018.12.013

LncRNAs in ovarian cancer

Clin Chim Acta. 2019 Mar:490:17-27. doi: 10.1016/j.cca.2018.12.013. Epub 2018 Dec 13.

Authors

Jin-Yan Wang¹, Ai-Qing Lu², Li-Juan Chen³

Affiliations

¹ Department of Obstetrics and Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, PR China; Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China.
² Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang 215600, PR China.
³ Department of Obstetrics and Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang 215600, Jiangsu, PR China. Electronic address: ljchen_doctor@163.com.

PMID: 30553863
DOI: 10.1016/j.cca.2018.12.013

Abstract

Ovarian cancer is one of the most common gynecologic malignancies and has a poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators of cancer development. Studies have shown that the dysregulation of lncRNAs is frequently observed in ovarian cancer and greatly contributes to malignant phenotypical changes. In this review, we provide perspectives on the involvement of lncRNAs in the proliferation, apoptosis, cell cycle, migration, invasion, metastasis and drug resistance of ovarian cancer based on recent discoveries. Then, we discuss the role of lncRNAs in predicting the prognosis of ovarian cancer. Finally, we provide insight into the potential of lncRNAs for evaluating the diagnosis and prognosis of ovarian cancer.

Keywords: Apoptosis; Diagnosis; LncRNAs; Metastasis; Ovarian cancer; Proliferation.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm
Female
Humans
Ovarian Neoplasms / drug therapy
Ovarian Neoplasms / genetics*
Ovarian Neoplasms / pathology
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding