Biological effects of mixed-ion beams. Part 2: The relative biological effectiveness of CHO-K1 cells irradiated by mixed- and single-ion beams

Joanna Czub; Dariusz Banaś; Janusz Braziewicz; Iwona Buraczewska; Marian Jaskóła; Urszula Kaźmierczak; Andrzej Korman; Anna Lankoff; Halina Lisowska; Zygmunt Szefliński; Maria Wojewódzka; Andrzej Wójcik

doi:10.1016/j.apradiso.2018.12.001

Biological effects of mixed-ion beams. Part 2: The relative biological effectiveness of CHO-K1 cells irradiated by mixed- and single-ion beams

Appl Radiat Isot. 2019 Aug:150:192-198. doi: 10.1016/j.apradiso.2018.12.001. Epub 2018 Dec 5.

Authors

Affiliations

¹ Jan Kochanowski University, Institute of Physics, ul. Świętokrzyska 15, 25-406 Kielce, Poland. Electronic address: czub@ujk.edu.pl.
² Jan Kochanowski University, Institute of Physics, ul. Świętokrzyska 15, 25-406 Kielce, Poland; Holy Cross Cancer Center, ul. Arwińskiego 3, 25-734 Kielce, Poland.
³ Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warsaw, Poland.
⁴ National Centre for Nuclear Research, ul. Andrzeja Sołtana 7, 05-400 Otwock-Świerk, Poland.
⁵ Heavy Ion Laboratory at the University of Warsaw, ul. Pasteura 5a, 02-093 Warsaw, Poland.
⁶ Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland; Institute of Nuclear Chemistry and Technology, ul. Dorodna 16, 03-195 Warsaw, Poland.
⁷ Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.
⁸ Department of Molecular Bioscience, Centre for Radiation Protection Research, The Wenner-Gren Institute, Stockholm University, Universitetsvagen 10, 114 18 Stockholm, Sweden; Jan Kochanowski University, Institute of Biology, ul. Świętokrzyska 15, 25-406 Kielce, Poland.

PMID: 30553541
DOI: 10.1016/j.apradiso.2018.12.001

Abstract

The relative biological effectiveness (RBE) values were determined for single- and mixed-ion beams containing carbon and oxygen ions. The CHO-K1 cells were irradiated with beams with the linear energy transfer (LET) values of 236-300 and 461-470 keV/μm for ¹²C and ¹⁶O ions, respectively. The RBE was estimated as a function of dose, survival fraction (SF) and LET. The SF was not affected by varying contributions of the constituent ions to the total mixed dose. The RBE has the same value for single-ion exposures with ions with LET 300 (¹²C) and 470 keV/μm (¹⁶O).

Keywords: CHO-K1 cells; Ions beams; Relative biological effectiveness.

MeSH terms

Animals
CHO Cells
Cell Survival / radiation effects
Cricetulus
Heavy Ion Radiotherapy* / statistics & numerical data
Heavy Ions
Ions / therapeutic use*
Linear Energy Transfer
Neoplasms / radiotherapy
Oxygen
Relative Biological Effectiveness*

Substances

Ions
Oxygen