Studies on the molecular dynamics of acetylated oligosaccharides of different topologies (linear versus cyclic)

Dawid Heczko; Ewa Kamińska; Aldona Minecka; Magdalena Tarnacka; Patrycja Waliłko; Anna Kasprzycka; Kamil Kamiński; Marian Paluch

doi:10.1016/j.carbpol.2018.10.118

Studies on the molecular dynamics of acetylated oligosaccharides of different topologies (linear versus cyclic)

Carbohydr Polym. 2019 Feb 15:206:273-280. doi: 10.1016/j.carbpol.2018.10.118. Epub 2018 Nov 2.

Authors

Dawid Heczko¹, Ewa Kamińska², Aldona Minecka³, Magdalena Tarnacka⁴, Patrycja Waliłko⁵, Anna Kasprzycka⁵, Kamil Kamiński⁴, Marian Paluch⁴

Affiliations

¹ Department of Pharmacognosy and Phytochemistry, Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, ul. Jagiellonska 4, 41-200 Sosnowiec, Poland. Electronic address: dawid.heczko@med.sum.edu.pl.
² Department of Pharmacognosy and Phytochemistry, Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, ul. Jagiellonska 4, 41-200 Sosnowiec, Poland. Electronic address: ekaminska@sum.edu.pl.
³ Department of Pharmacognosy and Phytochemistry, Medical University of Silesia in Katowice, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, ul. Jagiellonska 4, 41-200 Sosnowiec, Poland.
⁴ Silesian Center for Education and Interdisciplinary Research, University of Silesia, ul. 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland; Institute of Physics, University of Silesia, ul. 75 Pulku Piechoty 1, 41-500 Chorzow, Poland.
⁵ Silesian Technical University of Technology, Department of Chemistry, ul. Krzywoustego 4, 44-100 Gliwice, Poland; Biotechnology Centre, Silesian Technical University of Technology, ul. Krzywoustego 8, 44-100 Gliwice, Poland.

PMID: 30553322
DOI: 10.1016/j.carbpol.2018.10.118

Abstract

In this paper, the molecular dynamics and thermal properties of representative acetylated linear and cyclic oligosaccharides: acTRE, acRAF, acSTA, ac-α-CD, ac-β-CD, ac-γ-CD, have been investigated by using broadband dielectric spectroscopy and differential scanning calorimetry. We found that there are marked differences in the dynamics of the structural and secondary relaxation processes in both groups of materials. Just to mention a variation in the distribution of the structural relaxation times as well as different evolutions of the glass transition temperature (T_g) and fragility (m) versus molecular weight (M_w), which seem to be affected by the shape of the molecule, strain in the carbohydrate ring and mobility of side acetyl moieties.

Keywords: Acetylated linear and cyclic saccharides; Dielectric spectroscopy; Molecular dynamics; van der Waals systems.