Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer

Head Neck. 2019 Feb;41(2):309-314. doi: 10.1002/hed.25459. Epub 2018 Dec 14.

Abstract

Background: Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.

Methods: We analyzed serum MMP-8 (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow-up.

Results: Elevated S-MMP-8 level in RRP was associated with malignant transformation (P = .01). Compared to patients with RRP, S-MMP-8 in patients with LSCC was significantly higher (P < .001). Increased S-TIMP-1 level in LSCC was associated with poor overall survival (P = .02) and recurrence-free survival (P = .05).

Conclusion: In RRP, high S-MMP-8 may predict malignant transformation. In LSCC, elevated S-TIMP-1 is connected to poor survival.

Keywords: MMP-8; TIMP-1; biomarkers; laryngeal carcinoma; recurrent respiratory papilloma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Carcinoma, Squamous Cell / blood*
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / mortality
  • Cell Transformation, Neoplastic
  • Female
  • Humans
  • Laryngeal Neoplasms / blood*
  • Laryngeal Neoplasms / etiology
  • Laryngeal Neoplasms / mortality
  • Male
  • Matrix Metalloproteinase 8 / blood*
  • Middle Aged
  • Papillomavirus Infections / blood*
  • Papillomavirus Infections / mortality
  • Papillomavirus Infections / pathology*
  • Predictive Value of Tests
  • Respiratory Tract Infections / blood*
  • Respiratory Tract Infections / mortality
  • Respiratory Tract Infections / pathology*
  • Survival Rate
  • Tissue Inhibitor of Metalloproteinase-1 / blood*

Substances

  • Biomarkers
  • Tissue Inhibitor of Metalloproteinase-1
  • MMP8 protein, human
  • Matrix Metalloproteinase 8

Supplementary concepts

  • Recurrent respiratory papillomatosis