Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches

Matthew R Zeglinski; Adel Rezaei Moghadam; Sudharsana R Ande; Kimia Sheikholeslami; Pooneh Mokarram; Zahra Sepehri; Haleh Rokni; Nima Khadem Mohtaram; Mansour Poorebrahim; Anahita Masoom; Mehnosh Toback; Niketa Sareen; Sekaran Saravanan; Davinder S Jassal; Mohammad Hashemi; Hassan Marzban; Dedmer Schaafsma; Pawan Singal; Jeffrey T Wigle; Michael P Czubryt; Mohsen Akbari; Ian M C Dixon; Saeid Ghavami; Joseph W Gordon; Sanjiv Dhingra

doi:10.1002/cphy.c170053

Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches

Compr Physiol. 2018 Dec 13;9(1):75-125. doi: 10.1002/cphy.c170053.

Authors

Matthew R Zeglinski¹, Adel Rezaei Moghadam², Sudharsana R Ande³, Kimia Sheikholeslami^{2

4}, Pooneh Mokarram⁵, Zahra Sepehri^{2

6}, Haleh Rokni², Nima Khadem Mohtaram^{7

8}, Mansour Poorebrahim⁹, Anahita Masoom¹⁰, Mehnosh Toback¹¹, Niketa Sareen¹, Sekaran Saravanan^{1

12}, Davinder S Jassal¹, Mohammad Hashemi¹³, Hassan Marzban², Dedmer Schaafsma², Pawan Singal¹, Jeffrey T Wigle¹, Michael P Czubryt¹, Mohsen Akbari⁷, Ian M C Dixon¹, Saeid Ghavami^{2

14

15}, Joseph W Gordon^{2

16}, Sanjiv Dhingra¹

Affiliations

¹ St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.
² Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
³ Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
⁴ Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
⁵ Colorectal Research Center and Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
⁶ Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran.
⁷ Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, British, Columbia, Canada.
⁸ Department of System Design Engineering, Program of Biomedical Engineering, University of Waterloo.
⁹ Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
¹⁰ Faculty of Medicine, Mashhad Islamic Azad University, Mashhad, Iran.
¹¹ Foothills Hospital, Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada.
¹² CeNTAB, Department of Bioengineering, SCBT, SASTRA University, Thanjavur, India.
¹³ Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
¹⁴ Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada.
¹⁵ Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
¹⁶ College of Nursing and Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

PMID: 30549015
DOI: 10.1002/cphy.c170053

Abstract

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society. Compr Physiol 9:75-125, 2019.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Heart Failure / metabolism*
Heart Failure / pathology
Heart Failure / therapy
Humans
Myocardium / metabolism
Myocardium / pathology
Regenerative Medicine / methods*
Signal Transduction*
Tissue Engineering / methods*

Grants and funding

CIHR/Canada