Uptake and Tracer Kinetic of O-(2-(18)F-fluoroethyl)-L-Tyrosine in Meningioma

Clin Nucl Med. 2019 Jan;44(1):e22-e23. doi: 10.1097/RLU.0000000000002350.

Abstract

F-fluoroethyltyrosine (FET) is a well-established PET tracer for the imaging of cerebral gliomas. Recent studies reported interest in meningiomas. A study published by Cornelius et al concludes that FET PET may provide additional information for noninvasive grading of meningiomas. Indeed, the combination of tumor background ratio with a cutoff value of 2.3 associated with time activity curve pattern slightly improved the differentiation of high-grade from low-grade meningiomas (accuracy, 92%; P = 0.001). We present the case of a 75-year-old man that underlined the need to confirm the performance of these tools (curve pattern, tumor background ratios) to characterize meningiomas.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biological Transport
  • Glioma / pathology
  • Humans
  • Kinetics
  • Male
  • Meningeal Neoplasms / diagnostic imaging
  • Meningeal Neoplasms / metabolism*
  • Meningioma / diagnostic imaging
  • Meningioma / metabolism*
  • Positron-Emission Tomography
  • Radioactive Tracers
  • Tyrosine / analogs & derivatives*
  • Tyrosine / metabolism

Substances

  • O-(2-fluoroethyl)tyrosine
  • Radioactive Tracers
  • Tyrosine