Non-canonical nucleosides and chemistry of the emergence of life

Sidney Becker; Christina Schneider; Antony Crisp; Thomas Carell

doi:10.1038/s41467-018-07222-w

Non-canonical nucleosides and chemistry of the emergence of life

Nat Commun. 2018 Dec 12;9(1):5174. doi: 10.1038/s41467-018-07222-w.

Authors

Sidney Becker¹, Christina Schneider¹, Antony Crisp¹, Thomas Carell²

Affiliations

¹ Department of Chemistry at the Ludwig-Maximilians Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.
² Department of Chemistry at the Ludwig-Maximilians Universität München, Butenandtstr. 5-13, 81377, Munich, Germany. thomas.carell@lmu.de.

Abstract

Prebiotic chemistry, driven by changing environmental parameters provides canonical and a multitude of non-canonical nucleosides. This suggests that Watson-Crick base pairs were selected from a diverse pool of nucleosides in a pre-Darwinian chemical evolution process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry
Atmosphere / chemistry
Base Pairing
Earth, Planet*
Evolution, Chemical*
Models, Chemical
Molecular Structure
Nucleosides / chemistry*
Origin of Life*
RNA / chemical synthesis
RNA / chemistry

Substances

Amino Acids
Nucleosides
RNA