Cobalt-Catalyzed Hiyama-Type C-H Activation with Arylsiloxanes: Versatile Access to Highly ortho-Decorated Biaryls

Abstract

Versatile direct Hiyama-type C-H arylations of benzamides were accomplished with organosiloxanes by chelation-assisted cobalt catalysis. The C-H arylation featured broad substrate scope, including challenging C(sp³ )-H activation, the use of γ-valerolactone as biomass-derived solvent, and selectively provided the desired biaryls, even when being highly sterically hindered.

Keywords: C−H activation; biaryls; cobalt; silicon; steric hindrance.