Voriconazole hepatotoxicity as a result of steroid withdrawal in a patient with allergic bronchopulmonary aspergillosis

Br J Clin Pharmacol. 2019 Feb;85(2):460-462. doi: 10.1111/bcp.13819. Epub 2018 Dec 9.
No abstract available

Keywords: glucocorticoid; pharmacokinetic interaction; voriconazole.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged, 80 and over
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Aspergillosis, Allergic Bronchopulmonary / drug therapy*
  • Aspergillosis, Allergic Bronchopulmonary / immunology
  • Aspergillosis, Allergic Bronchopulmonary / microbiology
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cytochrome P-450 CYP2C19 / metabolism
  • Cytochrome P-450 CYP2C19 Inducers / pharmacology*
  • Cytochrome P-450 CYP2C19 Inducers / therapeutic use
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Glucocorticoids / pharmacology*
  • Glucocorticoids / therapeutic use
  • Humans
  • Prednisone / therapeutic use
  • Voriconazole / pharmacology*
  • Voriconazole / therapeutic use
  • Withholding Treatment

Substances

  • Antifungal Agents
  • Cytochrome P-450 CYP2C19 Inducers
  • Glucocorticoids
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Voriconazole
  • Prednisone