Long non coding RNAs and ALS: Still much to do

Stella Gagliardi; Cecilia Pandini; Maria Garofalo; Matteo Bordoni; Orietta Pansarasa; Cristina Cereda

doi:10.1016/j.ncrna.2018.11.004

Long non coding RNAs and ALS: Still much to do

Noncoding RNA Res. 2018 Nov 15;3(4):226-231. doi: 10.1016/j.ncrna.2018.11.004. eCollection 2018 Dec.

Authors

Stella Gagliardi¹, Cecilia Pandini^{1

2}, Maria Garofalo^{1

2}, Matteo Bordoni¹, Orietta Pansarasa¹, Cristina Cereda¹

Affiliations

¹ Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy.
² Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.

Abstract

Alterations in RNA metabolism play an important role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. The literature has described, so far, a small number of long non coding RNAs (lncRNAs) associated to ALS demonstrating that how there is still much to do to identify and understand their role in ALS. This class of RNAs may offer numerous starting points for new investigations about pathogenic mechanism involved in ALS disease. In this review, we have collected all the presented data about lncRNAs and ALS to offer an overview about this class of non-coding RNAs and their possible role in ALS disease.

Keywords: ALS; lncRNAs.

Publication types

Review