Sliding Crosslinked Thermoresponsive Materials: Polypseudorotaxanes Made of Poly(N-Isopropylacrylamide) and Acrylamide-γ-Cyclodextrin

Giulio Malucelli; Jvan Dore; Davide Sanna; Daniele Nuvoli; Mariella Rassu; Alberto Mariani; Valeria Alzari

doi:10.3389/fchem.2018.00585

Sliding Crosslinked Thermoresponsive Materials: Polypseudorotaxanes Made of Poly(N-Isopropylacrylamide) and Acrylamide-γ-Cyclodextrin

Front Chem. 2018 Nov 23:6:585. doi: 10.3389/fchem.2018.00585. eCollection 2018.

Authors

Giulio Malucelli¹, Jvan Dore², Davide Sanna², Daniele Nuvoli², Mariella Rassu², Alberto Mariani², Valeria Alzari²

Affiliations

¹ Department of Applied Science and Technology, Institute of Materials Science and Engineering for Innovative Technologies, Politecnico di Torino, Alessandria, Italy.
² Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.

Abstract

Novel polypseudorotaxanes (PPR) based on poly(N-isopropylacrylamide) (PNIPAAm) and acrylamide-γ-cyclodextrin (AγCD) are successfully synthesized. AγCD gives rise to sliding crosslinking systems and influences the thermoresponsive and swelling behavior of PNIPAAm hydrogels. Namely, their lower critical solution temperature (LCST) can be tuned up to 38°C, thus making the resulting materials of great interest in biomedical applications. Also, AγCD influences the thermal and mechanical properties of hydrogels, by affecting the T _g and E modulus values.

Keywords: LCST; PNIPAAm; cyclodextrin; hydrogel; polypseudorotaxane; thermoresponsive materials.