Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula

Abstract

Objective: To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [¹¹C]PBB3 as ligand.

Methods: This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Thirteen healthy men (69 ± 6 years) participated as healthy controls (HCs). Dynamic PET scans were performed following injection of [¹¹C]PBB3, and parametric PET images were generated by voxel-by-voxel calculation of binding potential (BP* _ND) using a multilinear reference tissue model. [¹¹C] Pittsburgh compound B (PiB) PET, MRI, and cognitive tests were also performed.

Results: A voxel-based comparison of [¹¹C]PBB3 BP* _ND illustrated PET-detectable tau deposition in the cerebral cortex and white matter, and pontine basis including the corticospinal tract in Kii ALS/PDC patients compared with HCs (uncorrected p < 0.05). Group-wise volume of interest analysis of [¹¹C]PBB3 BP* _ND images showed increased BP* _ND in the hippocampus and in frontal and parietal white matters of Kii ALS/PDC patients relative to HCs (p < 0.05, Holm-Sidak multiple comparisons test). BP* _ND in frontal, temporal, and parietal gray matters correlated with Mini-Mental State Examination scores in Kii ALS/PDC patients (p < 0.05). All Kii ALS/PDC patients were negative for [¹¹C]PiB (β-amyloid) except one with marginal positivity.

Conclusion: [¹¹C]PBB3 PET visualized the characteristic topography of tau pathology in Kii ALS/PDC, corresponding to clinical phenotypes of this disease.