Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

Biosci Rep. 2019 Jan 11;39(1):BSR20180201. doi: 10.1042/BSR20180201. Print 2019 Jan 31.

Abstract

Angiotensinogen (AGT) is the unique substrate of all angiotensin peptides. We review the recent preclinical research of AGT antisense oligonucleotides (ASOs), a rapidly evolving therapeutic approach. The scope of the research findings not only opens doors for potentially new therapeutics of hypertension and many other diseases, but also provides insights into understanding critical physiological and pathophysiological roles mediated by AGT.

Keywords: angiotensinogen; antisense oligonucleotides; cardiovascular disease; hypertension.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensinogen / antagonists & inhibitors
  • Angiotensinogen / genetics*
  • Angiotensinogen / metabolism
  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Genetic Therapy / methods*
  • Humans
  • Hypertension / genetics
  • Hypertension / metabolism
  • Hypertension / physiopathology
  • Hypertension / therapy*
  • Kidney / metabolism
  • Liver / metabolism
  • Molecular Targeted Therapy
  • Oligonucleotides, Antisense / chemical synthesis
  • Oligonucleotides, Antisense / genetics*
  • Oligonucleotides, Antisense / metabolism
  • Rats, Inbred SHR
  • Renin-Angiotensin System / genetics*

Substances

  • Antihypertensive Agents
  • Oligonucleotides, Antisense
  • Angiotensinogen