The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.
Keywords: 19q13 locus; HOXA2-PCAT19-CEACAM21 regulatory circuit; aggressive prostate cancer; integrated genomic analysis; rs11672691.