Potentiometric characterization of iodine-based disinfecting preparations

Waldemar Gottardi; Markus Nagl

doi:10.1016/j.jpba.2018.11.054

Potentiometric characterization of iodine-based disinfecting preparations

J Pharm Biomed Anal. 2019 Feb 20:165:90-93. doi: 10.1016/j.jpba.2018.11.054. Epub 2018 Nov 24.

Authors

Waldemar Gottardi¹, Markus Nagl²

Affiliations

¹ Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
² Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: m.nagl@i-med.ac.at.

PMID: 30513509
DOI: 10.1016/j.jpba.2018.11.054

Abstract

A potentiometric method is presented that allows to characterize aqueous iodine-based disinfecting solutions and preparations, respectively. By means of three electrodes (iodide-sensitive, platinum redox, and reference electrode), the concentrations of free iodine, iodide, and triiodide were determined. The apposition "free" means iodine not complexed with ligands originating from the organic matrix of the iodophoric iodine source (e.g. povidone iodine). Based on the gained values ([I₂], [I^-], and[I₃^-]), it is possible to assess features concerning kinetics of disinfection, disinfecting capacity, and tolerability. The method distinguishes by simplicity and modest time expenditure of 10-15 min for a complete investigation comprising two potentiometric measurements.

Keywords: Iodide; Iodine; Potentiometry; Triiodide.

Publication types

Comparative Study

MeSH terms

Disinfectants / chemistry*
Disinfectants / pharmacology
Electrodes
Iodine / chemistry*
Oxidation-Reduction
Potentiometry / methods*
Povidone-Iodine / chemistry*
Povidone-Iodine / pharmacology
Time Factors

Substances

Disinfectants
Povidone-Iodine
Iodine