Endosomal Sorting: Architecture of the Retromer Coat

Boris Simonetti; Peter J Cullen

doi:10.1016/j.cub.2018.10.040

Endosomal Sorting: Architecture of the Retromer Coat

Curr Biol. 2018 Dec 3;28(23):R1350-R1352. doi: 10.1016/j.cub.2018.10.040.

Authors

Boris Simonetti¹, Peter J Cullen²

Affiliations

¹ School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK.
² School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol BS8 1TD, UK. Electronic address: Pete.Cullen@bristol.ac.uk.

PMID: 30513333
DOI: 10.1016/j.cub.2018.10.040

Abstract

Retromer is a master regulator of endosomal cargo sorting. Using cryo-EM, a new study now reveals how, in yeast, this multiprotein complex is assembled on tubular membranes to form a coat complex that orchestrates the process of tubular-based cargo sorting.

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Comment

MeSH terms

Electron Microscope Tomography*
Endosomes
Protein Transport
Sorting Nexins*
Vesicular Transport Proteins

Substances

Sorting Nexins
Vesicular Transport Proteins