Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp

Quan Zhang; Lin-Fu Liang; Ze-Hong Miao; Bin Wu; Yue-Wei Guo

doi:10.1016/j.steroids.2018.11.015

Cytotoxic polyhydroxylated steroids from the South China Sea soft coral Lobophytum sp

Steroids. 2019 Jan:141:76-80. doi: 10.1016/j.steroids.2018.11.015. Epub 2018 Dec 1.

Authors

Quan Zhang¹, Lin-Fu Liang², Ze-Hong Miao³, Bin Wu⁴, Yue-Wei Guo⁵

Affiliations

¹ Ocean College, Zhejiang University, Hangzhou 310058, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
⁴ Ocean College, Zhejiang University, Hangzhou 310058, China. Electronic address: wubin@zju.edu.cn.
⁵ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. Electronic address: ywguo@simm.ac.cn.

PMID: 30513321
DOI: 10.1016/j.steroids.2018.11.015

Abstract

Four new polyhydroxylated steroids lobophysterols A-D (1-4), together with two known related compounds sarcophytosterol (5) and klyflaccisteroid B (6), were isolated from the South China Sea soft coral Lobophytum sp. Their structures were elucidated on the basis of spectroscopic analysis and by comparison with those reported in the literature. In bioassay, compound 4 showed weak cytotoxicities against HT-29, SNU-398, and Capan-1 cells.

Keywords: Cytotoxicity; Lobophysterols A–D; Lobophytum sp.; Polyhydroxylated steroids; Soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
China
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Oceans and Seas
Structure-Activity Relationship

Substances

Antineoplastic Agents