Our patient is a 45-year-old woman with a history of Loeys-Dietz syndrome, vertebral artery dissection, stroke, prior atrial septal defect repair, and spontaneous left main coronary artery dissection that was revascularized with coronary artery bypass grafting who progressed to end-stage heart failure. She was listed for cardiac transplantation, and a suitable organ became available. She underwent heart transplantation more than 1 year ago successfully. This is the first reported case of a successful heart transplantation in an individual with Loeys-Dietz syndrome.
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